Deliverable No
Deliverable Title
D1.1
Periodic EC report first period (Activity report, Management report, report on distribution of EC contribution);
D1.2
Final EC report (Activity report, Management report, report on distribution of EC contribution);
D1.3.x
One Audit certificate per contractor per reporting period (in total 36);
D1.4.x
Six project progress reports to Project Steering group (bi-annual);
D2.1
Report on the population structure of E. faecalis and the role of hypermutation on the establishment of clonal complexes
D2.2
Improved MLST scheme for E. faecium and E. faecalis with an improved resolution based on polymorphism in housekeeping genes and virulence genes
D2.3
New HiRECC
D3.1
A typing scheme for resistance plasmids
D3.2
A catalogue of resistance determinants, transposons and plasmids present in different host groups (humans (hospital and non-hospital) animals and the environment)
D3.3
Report on the conditions and efficacy of intra- and inter-species transfer of antibiotic resistance
D4.1
In vitro and in vivo models to determine increased fitness costs related to different hospital environmental subspaces.
D4.2
A list of commensals that inhibit growth of HiRECC
D4.3
Report on which bacterial determinants promote hospital adaptation of enterococci in hospital environmental subspaces
D5.1
List of HiRECC associated genes.
D5.2
A redesigned E. faecium microarray, containing more genes from other E. faecium strains including plasmid encoding genes and the E. faecium PAI associated genes.
D5.3
List of candidate molecules for immunotherapy
D5.4
Report on relations between virulence factor expression and growth conditions.
D5.5
Collection of HiRECC mutants
D5.6
New methods to generate ‘mutants” in E. faecalis and E. faecium
D6.1
A novel method to control colonization of multi-resistant HiRECC using probiotics
D7.1
Novel passive vaccination approach to treat infections with multi-resistant HiRECC
D7.2
Novel active vaccination approach in specific patients groups to reduce colonization with multi-resistant HiRECC.
