Sixth Framework Programme
Life Sciences, Genomics and Biotechnology for Health
Approaches to Control multi-resistant Enterococci:
Studies on molecular ecology, horizontal gene transfer, fitness and prevention

Project number: LSHE-CT-2007-037410

ACE news

> ACE Annual Meeting 23-25 April 2008

> Kees Leenhouts and Maarten van Rosmalen have left Biomade.
Tjibbe Bosma is now Biomade's projectleader for the ACE project

ACE meetings

Participating institutes

For restricted users

> People
> Downloads
> Strain Database
> Scientific publications
Vancomycin-reistant enterococci (VRE) have become the paradigm of the post-antibiotic era. Nosocomial VRE-infections are rising in all European countries, with proportions >10% among enterococcal bloodstream infections in 5 countries in 2004. From a microbial perspective, emergence of VRE represents a dual-edged sword: they are amongst the most resistant opportunistic nosocomial pathogens with an increasing impact on patients' health care. Moreover, and maybe even more important, their unprecedented capacity of genetic exchange make them perfect hubs for resistance genes facilitating horizontal gene transfer amongst bacterial species.

The mission of the consortium is "To gain new and improved understanding of the ecology of antibiotic resistance with the aim of developing novel approaches in controlling spread of multi-resistant enterococcal clones and transmission of the resistance genes harboured by them".