Sixth Framework Programme
Life Sciences, Genomics and Biotechnology for Health
Approaches to Control multi-resistant Enterococci:
Studies on molecular ecology, horizontal gene transfer, fitness and prevention
Project number: LSHE-CT-2007-037410
ACE meetings
Participating institutes
Vancomycin-reistant enterococci (VRE) have become the
paradigm of the post-antibiotic era. Nosocomial VRE-infections are rising
in all European countries, with proportions >10% among enterococcal bloodstream
infections in 5 countries in 2004. From a microbial perspective, emergence
of VRE represents a dual-edged sword: they are amongst the most resistant
opportunistic nosocomial pathogens with an increasing impact on patients'
health care. Moreover, and maybe even more important, their unprecedented
capacity of genetic exchange make them perfect hubs for resistance genes facilitating
horizontal gene transfer amongst bacterial species.
The mission of the consortium is "To gain new and improved understanding
of the ecology of antibiotic resistance with the aim of developing novel approaches
in controlling spread of multi-resistant enterococcal clones and transmission
of the resistance genes harboured by them".